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R&D Activities - Organic Chemicals Division -

Agrochemicals

In our involvement in agrochemical research, also dubbed as “Chemistry that grows lives,” we contribute to solving food security issues that are becoming increasingly serious.

We are engaged in research and development to create safe and effective agrochemicals by recognizing that agrochemicals are indispensable to food security and stability in the world.

Our laboratories are working cohesively to discover and develop new agrochemicals: the Chemical Science Laboratory explores new agrochemicals, the Bioscience Research Laboratory accelerates the pipeline development of agrochemicals and expands the applications of existing agrochemicals, Process Development Laboratory studies the manufacturing process of agrochemicals, the Formulation Research Laboratory investigates formulations that maximize agrochemical performance, and the Safety Science Research Laboratory assesses the initial safety of agrochemicals.

Regarding the discovery of new agrochemicals, we have persistently discovered innovative agrochemicals using computer-assisted drug design, bioscientific and molecular biological approaches in addition to our organic synthetic methods have been acknowledged for the synthesis of trifluoromethylpyridine derivatives.

To develop our newly discovered agrochemicals at the global level, our Safety Science Research Laboratory plays a leading role in helping their speedy approval in each country through safety assessment and environmental science research. These efforts have successfully led to the development, approval, commercialization, and marketing of many agrochemicals worldwide.

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Agrochemicals Developed In-house(dummy)
Herbicide for paddy fields
Pyrazoxyfen, PAICER, 1985, 3 countries
Used as a base agent for ONEBEST, ONEALL, and TOBIKIRIJUMBO, pyrazoxyfen helps inhibit weed growth in wide areas for a long time period, thus streamlining field work.
Herbicides for upland farming, fruit cultivation, and turf growing
Fluazifop-P-butyl, ONESIDEP, 1986, 20 countries
Strongly active for a wide variety of grassy weeds ranging from annuals to perennials, Fluazifop-P-butyl has been used worldwide in farms growing soybeans, cottons, beets, and other broadleaf crops.
Flazasulfuron, SHIBAGEN, 1989, 35 countriesPDF
As a sulfonylurea herbicide, flazasulfuron is used at very low dose and provides long-term herbicidal effects on a wide variety of weeds in orchards, warm-season turf, and non-crop areas.
Nicosulfuron, ONEHOPE, 1994, 58 countriesPDF
Nicosulfuron is a sulfonylurea herbicide which is exclusively used for maize. It acts on grassy and broadleaf weeds at the same time. Its performance has been acknowledged in major worldwide markets including Europe, Central and South America, and Japan.
Insecticides/Nematicides
Chlorfluazuron, ATABRON, 1988, 34 countriesPDF
Chlorfluazuron is one of our groundbreaking insect growth regulators. It inhibits the biosynthesis of chitin, a material contained in the outer skin of insects. It has strong insecticidal activity against lepidopteran, thysanopteran, and hemipteran larvae.
Fosthiazate, NEMATHORIN, 1992, 36 countriesPDF
Fosthiazate is a low-toxicity organophosphorous insecticide. Low concentration levels of this non-fumigating agent are effective against all nematode development stages. Because fosthiazate is systemic in plants, its soil application acts on ground pests like spider mites, Thrips palm Karnyi, and greenhouse whiteflies.
Flonicamid, ULALA, 2003, 32 countriesPDF
Flonicamid is an insecticide that enables integrated pest management (IPM) because it exhibits low activity against natural enemies and insect pollinators. It is highly active against sup-sucking Hemiptera and Thysanoptera bugs, especially aphids. Its unique action inhibits sup sucking, thus providing the insecticidal effect. Flonicamid also acts on resistant strains, because its mode of action differs from previous insecticides.
Fluazinam, FROWNCIDE, 1990, 58 countries
Fluazinam, FROWNCIDE, 1990, 58 countriesPDF
Fluazinam is a protective pyridinamine fungicide that acts on a broad spectrum of fungi. It is effective against diseases that have become resistant to other agents. It is also active against diseases that are difficult to control like the root rot of fruit trees and the bacteria gall of Brassicaceae vegetable roots. It is recognized as a mitecide for controlling potato late blight in Europe and Japan.
Cyazofamid, RANMAN, 2001, 55 countriesPDF
With a phenylimidazole skeleton, cyazofamid is high selective and effective against Oomycetes which cause downy mildew and late blight, and Plasmodiophoromycetes which induce bacteria gall of Brassicaceae vegetable roots). Its novel mode of action consists in inhibiting the Qi site of mitochondrial complex III in the intramitochondrial electron transport system.
Biological insecticides We help the development of environmentally conservative agrochemical practices that use natural enemies like Phytoseiulus persimilis Athias-Henriot, Encarsia formosa Gaha, Aphidius colemani Viereck, and Diglyphus isaea against spider mites, greenhouse whiteflies, aphids, and leaf miners.
Research Achievements
Achievement Award from the Pesticide Science Society of Japan
1987:
Development of the Fluazifop herbicide
1992:
Development of the Chlorfluazuron insect growth regulator
1998:
Development of the Fosthiazate insecticide/nematicide
2000:
Development of the Nicosulfuron herbicide
2004:
Development of the Cyazofamid fungicide
Okochi Memorial Technology Prize
1989:
Development of industrial manufacturing methods for 2-chloro-5-trifluoromethylpyridine—a valuable intermediate for a bioactive substance
Minister of Japanese Agriculture, Forestry and Fisheries Prize
1993:
2Introduction and granulation of 2,4-D
(2,4-D Industry-government-academia Research Group)

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Life Sciences

Life-Science Laboratory

Research and development of medical materials and bio-reagents for diagnostics

Life-Science Laboratory
Medical materials for artificial bones

The application of inorganic materials research to medical technology has been thriving in recent years. Titanium dioxide, one of ISK’s core products, presents a wide range of attractive characteristics. It is classified as an inorganic drug in the Pharmacopeia of Japan and has been used as an encapsulated opacifier. We are working with our Inorganic Chemicals Division on the development of medical materials using existing technologies based on titanium dioxide, which has been shown to be optimal for medical application.

We are focusing on one of the characteristics of titanium oxide, in particular its tendency to facilitate in vivo apatite formation for artificial bones.

“GenomONE” bio-reagent series for HVJ envelope

In April 2002, we started manufacturing and selling GenomONE—a transfection kit for gene function analysis which was followed by GenomONE-Neo. GenomONE is the fruit of an industry–academia joint development program with Osaka University, Japan, and its bio venture. In February 2006, we also launched the GenomONE-CF cell fusion kit and, in October 2007, the GenomONE-CAb transfection kit for specific antibody delivery.

In the Life-Science Laboratory, we have been working on the research and development of the GenomONE series to enhance vector function performance. We are focusing on adding an in vivo drug delivery system and, in addition to genes, achieving high efficiency transfection for proteins and other substances.

We are also exploring the creation of new antibodies by synthesizing GenomONE-CF-based hybridomas. Furthermore, we have been involved in industry-government-academia joint research to develop new diagnostic agents.

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