Animal Health Products

images: Medicinal Products for Animal Use

Taking advantage of our new pesticide discovery technology that we have fostered so far, we have developed (fuzapladib), an anti-pancreatitis drug for dogs.
We provide excellent products that the owners of companion animals and animal healthcare professionals depend on.

Fuzapladib Sodium Hydrate

In September 2018, we obtained manufacturing/marketing approval for this drug with the effect of “improvement of clinical signs in the acute phase of pancreatitis in dogs”.
Fuzapladib blocks activation of adhesion molecules (integrin) expressed on the inflammatory cell surface to prevent inflammatory cells from adhering to vascular endothelial cells and infiltrating tissue and to control exacerbation of pancreatitis.
This mode of action is different from that of conventional anti-inflammatory drugs including steroids and non-steroid anti-inflammatory drugs (NSAIDs).
No veterinary drugs with a similar action mechanism is available anywhere in the world, including Japan.

IUPAC name N-[2-(ethylsulfonylamino)-5-(trifluoromethyl)-3-pyridinyl]cyclohexanecarboxamide mono sodium salt monohydrate
Molecular weight 419.40
Molecular formula C15H19F3N3NaO3S・H2O
CAS RN 351999-87-6
Development code IKV-741, IS-741, SH-741

Fuzapladib sodium hydrate is the active pharmaceutical ingredient in ISK’s animal health product, BRENDA™, which ISK manufactures and distributes in Japan. ISK also supplies fuzapladib sodium hydrate to Nippon Zenyaku Kogyo Co., LTD as drug substance for BRENDA™Z.